5J 4 是一种有效的 CRAC 抑制剂。
货号:ajcx27074
CAS:827001-82-1
分子式:C16H12N2O3S
分子量：312.34
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID:24307733