A neuropeptide with diverse biological activities
货号:ajcx23390
CAS:N/A
分子式:C20H17D4FN6O5
分子量：448.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Raltegravir-d₄is intended for use as an internal standard for the quantification of raltegravir by GC- or LC-MS. Raltegravir is an orally bioavailable inhibitor of HIV-1 integrase (IC₅₀= 15 nM in a strand transfer assay).¹It inhibits the spread of HIV-1IIIb infection in MT-4 cell culture with 95% cell culture inhibitory concentration (CIC₉₅) values of 19 and 31 nM in medium containing 10% heat-inactivated fetal bovine serum (FBS) or 50% normal human serum, respectively. Formulations containing raltegravir have been used in combination therapy in the treatment of HIV-1 infection.

1.Summa, V., Petrocchi, A., Bonelli, F., et al.Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infectionJ. Med Chem.1(18)5843-5855(2008)