雷洛昔芬-d4（盐酸盐）是氘标记的雷洛昔芬。雷洛昔芬 (Keoxifene) 是苯并噻吩衍生的选择性雌激素受体调节剂 (SERM)。雷洛昔芬对骨骼和脂质具有雌激素激动作用，对乳房和子宫具有雌激素拮抗作用。雷洛昔芬用于乳腺癌和骨质疏松症研究。
货号:ajcx23388
CAS:1188263-47-9
分子式:C28H23D4NO4S.HCl
分子量：514.1
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Raloxifene-d₄is intended for use as an internal standard for the quantification of raloxifene by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.¹Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED₅₀= 0.2 mg/kg).^2,1Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.³

1.Black, L.J., Sato, M., Rowley, E.R., et al.Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ratsJ. Clin. Invest.93(1)63-69(1994) 2.Wong, C.M., Yung, L.M., Leung, F.P., et al.Raloxifene protects endothelial cell function against oxidative stressBr. J. Pharmac.155(3)326-334(2008) 3.Özmen, B., Kirmaz, C., Aydin, K., et al.Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-ß1 and bone turnover markers in the treatment of postmenopausal osteoporosisEur. Cyto. Netw.18(3)148-153(2007)