A neuropeptide with diverse biological activities
货号:ajcx21054
CAS:N/A
分子式:C18H16D17NO4
分子量：344.6
溶解度:Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

10-Nitrooleate-d₁₇contains 17 deuterium atoms at the 11, 11, 12, 12, 13, 13, 14, 14, 15, 15, 16, 16, 17, 17, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of 10-nitrooleate by GC-or LC-mass spectrometry. Nitrated unsaturated fatty acids, such as 10-and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO₂isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide.^1,2,3,410-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (OA-NO₂; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportionsin vivo.⁵Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H₂O₂and nitrite, all mediate the nitration of oleic acid. OA-NO₂is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO₂activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.⁵

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