IP7e 是一种有效的、脑渗透性和口服活性的 Nurr1 激活剂，EC50 值为 3.9 nM。
货号:ajcx20416
CAS:500164-74-9
分子式:C23H22N2O4
分子量：390.4
溶解度:DMSO: 100 mM,Ethanol: 20 mM, warmed
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IP7e is a brain-penetrant activator of nuclear receptor related protein 1 (Nurr1/NR4A2) signaling (EC50 = 3.9 nM in a reporter assay).1 In vivo, IP7e (10 mg/kg) prevents spinal cord axonal loss and demyelination and decreases spinal cord macrophage and T cell infiltration in a mouse model of experimental autoimmune encephalomyelitis (EAE).2

|1. Hintermann, S., Chiesi, M., von Krosigk, U., et al. Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorg. Med. Chem. Lett. 17(1), 193-196 (2007).|2. Montarolo, F., Raffaele, C., Perga, S., et al. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice. PLoS One 9(9), e108791 (2014).