Burixaforhydrobromide(TG-0054hydrobromide)是具有口服活性的、有效的CXC族趋化因子受体4(CXCR4)的拮抗剂，是一种具有潜在治疗脉络膜新生血管的水溶性抗血管生成药物。Burixaforhydrobromide(TG-0054hydrobromide)能够在猪心肌梗死模型中，动员间充质干细胞，减轻炎症反应，维持心脏的收缩功能。
货号:ajcx12426
CAS:1191450-19-7
分子式:C27H51N8O3P.xHBr
分子量：N/A
溶解度:H2O : 50 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization[1]. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction[2].

[1]. Shelke NB, et al. Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases. Drug Deliv Transl Res. 2011 Feb;1(1):76-90. [2]. Hsu WT, et al. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28.