Stafib-2

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Stafib-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	644.46

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Stafib-2 是一种有效和选择性的转录因子 STAT5b 抑制剂，抑制 STAT5b 和 STAT5a 的 IC50 值分别为 82 nM 和 1.7 μM。Stafib-2 的细胞通透性较差。
货号:ajcx35222
CAS:2097938-74-2
分子式:C28H26N2O12P2
分子量：644.46
溶解度:DMSO : 50 mg/mL (77.58 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability[1].

Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM)[1].Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells[1].

[1]. Elumalai N, et, al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.