DP-C-4 是一种基于 Cereblon 的双 PROTAC，用于同时降解 EGFR 和 PARP。
货号:ajcx34710
CAS:N/A
分子式:C72H78ClF2N15O14
分子量：1450.93
溶解度:DMSO : 12 mg/mL (8.27 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].

DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].

[1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.