QPX7728-OH disodium，一种硼酸类β-内酰胺酶 (β-lactamase) 抑制剂。QPX7728-OH disodium 抑制纯化的A、C、D类酶对 Nitrocefin 的裂解，Kis≤0.1 µμ。
货号:ajcx33326
CAS:2170848-99-2
分子式:C10H6BFNa2O5
分子量：281.94
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

QPX7728-OH disodium (compound 13) is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 13. QPX7728-OH disodium inhibits cleavage of Nitrocefin by purified class A, C and D enzymes, with Kis less than 0.1 µμ[1].

QPX7728-OH disodium potentiates Aztreonam and Tigemonam against strains expressing class A and class C enzymes, with MICs≤5 µg/mL. QPX7728-OH disodium potentiates Biapenem against strains expressing class A (KPC) or class D (OXA-48) carbapenemases, with MICs≤5 µg/mL[1].

[1]. Scott Hecker, et al. Boronic acid derivatives and therapeutic uses thereof. WO2018005662A1.