Diloxanide是一种抗原虫制剂(anti-protozoalagent)，可用于组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病的研究。Diloxanide是一种活性的鲁米那抗阿米巴试剂，在胃肠道中，由其前药二氯尼特糠酸酯水解得来。
货号:ajcx30534
CAS:579-38-4
分子式:C9H9Cl2NO2
分子量：234.08
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate [1].

Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1].Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].

[1]. DB08792 [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.