Br-C3-methylester是一种PROTAClinker，属于Alkyl/ether类。可用于合成PROTACPD-1/PD-L1degrader-1。
货号:ajcx30310
CAS:4897-84-1
分子式:C5H9BrO2
分子量：181.03
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Br-C3-methyl ester is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 [1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.