Acid-PEG3-C2-Boc是一种PROTAClinker，属于PEG和Alkyl/ether类，可以用于合成降解EGFR和抑制mTOR的PROTAC。
货号:ajcx30118
CAS:1807539-06-5
分子式:C14H26O7
分子量：306.35
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.