L-319 是一种可离子化的阳离子类脂质,可用于合成脂质体,来自专利 WO-2011153493-A2,化合物 1。
货号:ajcx26372
CAS:1351586-50-9
分子式:C41H75NO6
分子量:678
溶解度:Chloroform: soluble
纯度:98%
存储:Store at -20°C
库存:
现货Background:
L-319 is an ionizable (pKa= 6.38) and biodegradable lipid that has been used in the formation of lipid nanoparticles.1Administration of mouse factor VII-targeting siRNA in L-319-containing lipid nanoparticles induces factor VII silencing in mice.
1.Maier, M.A., M., J., Matsuda, S., et al.Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeuticsMol. Ther.21(8)1570-1578(2013)