A metabolite of sertraline
货号:ajcx26110
CAS:675126-09-7
分子式:C16H15Cl2N • HCl
分子量：328.7
溶解度:DMSO: slightly,Methanol: slightly
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-desmethyl Sertraline is a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline .¹It is formed from sertraline primarily by the cytochrome P450 (CYP) isoform CYP2B6 and to a lesser extent by CYP2C19, -2C9, -2D6, and -3A in human liver microsomes. N-desmethyl Sertraline has been found in wastewater effluent.²

1.Obach, R.S., Cox, L.M., and Tremaine, L.M.Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro studyDrug Metab. Dispos.33(2)262-270(2005) 2.Lajeunesse, A., Gagnon, C., and SauvÉ, S.Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometryAnal. Chem.80(14)5325-5333(2008)