The lactone form of rosuvastatin
货号:ajcx25192
CAS:503610-43-3
分子式:C22H26FN3O5S
分子量：463.5
溶解度:DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin .¹It is foundin vivofollowing rosuvastatin administration.²Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC₅₀s = 8.52 and 4.1 µM, respectively).¹

1.Shiozawa, A., Yamaori, S., Kamijo, S., et al.Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)Drug Metab. Pharmacokinet.36100364(2021) 2.Martin, P.D., Warwick, M.J., Dane, A.L., et al.Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteersClin. Ther.25(11)2822-2835(2003)