C27H21D7N2O7
货号:ajcx24116
CAS:N/A
分子式:C27H21D7N2O7
分子量：499.6
溶解度:DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cilnidipine-d₇is intended for use as an internal standard for the quantification of cilnidipine by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.¹Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.²It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.³Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

1.Murai, Y., Uneyama, H., Ishibashi, H., et al.Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipineBrain Res.854(1-2)6-10(1999) 2.Hosono, M., Hiruma, T., Watanabe, K., et al.Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive ratsJpn. J. Pharmacol.69(2)119-125(1995) 3.Takahara, A., Konda, T., Enomoto, A., et al.Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia modelBiol. Pharm. Bull.27(9)1388-1391(2004)