An agonist of TLR1/TLR2
货号:ajcx23878
CAS:2170867-89-5
分子式:C56H56N6O6
分子量：909.1
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.¹It induces TNF-α release in THP-1 cells (EC₅₀= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2^-/-, mice sensitized to ovalbumin.²It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model.

1.Morin, M.D., Wang, Y., Jones, B.T., et al.Diprovocims: A new and exceptionally potent class of toll-like receptor agonistsJ. Am. Chem. Soc.140(43)14440-14454(2018) 2.Wang, Y., Su, L., Morin, M.D., et al.Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in miceProc. Natl. Acad. Sci. U.S.A.115(37)E8698-E8706(2018)