An NSAID and COX inhibitor
货号:ajcx22766
CAS:167105-81-9
分子式:C15H12NO3.1/2Ca
分子量：274.3
溶解度:DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC₅₀= 20 nM for both COX-1 and COX-2).¹It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E₂(PGE₂) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.

1.Zhang, Y., Shaffer, A., Portanova, J., et al.Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 productionJ. Pharmacol. Exp. Ther.283(3)1069-1075(1997)