An internal standard for the quantification of atorvastatin
货号:ajcx21740
CAS:222412-82-0
分子式:C29H30D5FN2O5.1/2Ca
分子量：582.7
溶解度:DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 0.50 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Atorvastatin-d₅is intended for use as an internal standard for the quantification of atorvastatin by GC- or LC-MS. Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC₅₀values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.¹Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.

1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)