An inhibitor of NGF-p75 NGFR interactions
货号:ajcx20716
CAS:N/A
分子式:C19H14N4O4 • XH2O
分子量：362.3
溶解度:DMSO: 36 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PD 90780 is an inhibitor of the interaction between NGF and the p75 NGF receptor (NGFR).1 It binds to NGF (KD = 25.83 μM) and inhibits NGF binding to the extracellular domain of p75 NGFR (IC50 = 220 nM), as well as to Q1-CHO cells expressing full-length human p75 NGFR (IC50 = 300 nM).1,2 PD 90780 inhibits NGF-dependent differentiation of PC12 cells (IC50 = 33.22 μM).2