IFNalpha-IFNAR-IN-1盐酸盐是IFNalpha和其受体IFNAR相互作用抑制剂，EC50值2-8μM。
货号:ajcx13348
CAS:N/A
分子式:C18H18ClNS
分子量：315.86
溶解度:DMSO : 125 mg/mL (395.74 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.