CMPD7是有效，选择性的CDK12抑制剂，酶试验IC50值为491nM。
货号:ajcx12996
CAS:2220184-50-7
分子式:C23H28F2N8O
分子量：470.52
溶解度:DMSO: 250 mg/mL (531.33 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].

[1]. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.