Belvarafenib是一种有效的，广泛的迅速加速纤维肉瘤激酶(RAF)的抑制剂，其对B-RAF，B-RAFv600E和C-RAF的IC50值分别为56nM,7nM和5nM。
货号:ajcx12860
CAS:1446113-23-0
分子式:C23H16ClFN6OS
分子量：478.93
溶解度:DMSO: 12.5 mg/mL (26.10 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

[1]. WO 2013/100632 A1.