GNE5729是一种可透过血脑屏障的NMDAR的正向调节剂，对GluN2A的EC50值为37nM，对GluN2C和GluN2D的EC50值分别为4.7和9.5μM。
货号:ajcx12478
CAS:2026635-66-3
分子式:C17H10Cl2F3N5O
分子量：428.2
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1].

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.