RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。
货号:ajcx33646
CAS:N/A
分子式:C30H25ClN4O7
分子量：589
溶解度:DMSO : 125 mg/mL (212.22 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].

[1]. Ravi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15(1):e0227727.