Thalidomide-NH-PEG4-COOH 是一种 E3 连接酶配体-linker 偶联物，可用于合成 dCBP-1。dCBP-1 是一种有效且选择性的 p300/CBP 异双功能降解剂。
货号:ajcx33260
CAS:2412056-48-3
分子式:C24H31N3O10
分子量：521.52
溶解度:DMSO : 80 mg/mL (153.40 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].

Thalidomide-NH-PEG4-COOH (S13) is the E3 ligase ligand-linker conjugate of dCBP-1[1].

[1]. Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4.