Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
货号:ajcx32602
CAS:52811-37-7
分子式:C14H12O4
分子量：244.24
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

Cearoin (10-80 µM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 µM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 µM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].

参考文献:
[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.