MSN-125是有效的Bax和Bak低聚抑制剂。MSN-125可防止线粒体外膜通透性(MOMP)，IC50为4μM。MSN-125有效抑制HCT-116，BMK细胞和原代皮层神经元中Bax/Bak介导的凋亡，保护原代神经元免受谷氨酸兴奋性毒性。
货号:ajcx31126
CAS:1592908-16-1
分子式:C36H38BrN3O6
分子量：688.61
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].

MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].

[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.