MDNI-caged-L-glutamate (MDNI-glu) 是主要兴奋性氨基酸 L-谷氨酸的一种生物惰性、光敏衍生物。
货号:ajcx27232
CAS:864085-92-7
分子式:C14H16N4O8
分子量：368.3
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Rapidly and efficiently releases glutamate when photolysed (350 - 365 nm excitation). Water soluble and stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to 200 μM). 5.5 times more photosensitive than MNI-caged L-glutamate . Laser activation of MDNI-glu evokes a rapid increase in intracellular Ca2+ concentration in astrocytes.

Fedoryak et al (2005) Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells. Chem. Commun. (Camb.) 7 3664 PMID:16027904 |Papageorgiou et al (2005) Synthetic and photochemical studies of substituted 1-acyl-7-nitroindolines. Photochem.Photobiol.Sci. 4 887 PMID:16252044 |Popovic et al (2015) Electrical behaviour of dendritic spines as revealed by voltage imaging. Nat.Commun. 6 8436 PMID:26436431