A bacterial metabolite with diverse biological activities
货号:ajcx25144
CAS:5467-84-5
分子式:C17H20N2O
分子量：268.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N,N’-Diphenethylurea is a bacterial metabolite that has been found inStreptomycesand has diverse biological activities.¹It inhibitsStreptomyceschitin synthase 1 (IC₅₀= 14 µg/ml) but notC. albicanschitin synthase 2 when used at concentrations up to 280 µg/ml. N,N’-Diphenethylurea is active against the fungusC. neoformansand the plant pathogenic fungusR. solani(MIC = 50 µg/ml for both).²It enhances insulin-induced adipocyte differentiation in 3T3-L1 and C3H/10T1/2 cells when used at concentrations of 30 and 100 µM.³

1.Iwai, Y., Hirano, A., Awaya, J., et al.1,3-Diphenethylurea from Streptomyces sp. No. AM-2498J. Antibiot. (Tokyo)31(4)375-376(1978) 2.Kim, N.R., Hwang, E.I., Bong, S.K., et al.Isolation of Candida albicans chitin synthase 1 inhibitor from Steptomyces sp. A6705 and its characterizationJ. Microbiol. Biotechnol.15(4)895-898(2005) 3.Choi, S.-S., Cha, B.-Y., Kagami, I., et al.N,N’-diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-L1 cellsJ. Antibiot. (Tokyo)64(3)277-280(2011)