A neuropeptide with diverse biological activities
货号:ajcx23726
CAS:N/A
分子式:C5[13C]H9D2NO2.HCl
分子量：168.6
溶解度:Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Vigabatrin-¹³C-d₂is intended for use as an internal standard for the quantification of vigabatrin by GC- or LC-MS. Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor.¹It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T overP. fluorescensGABA-T at 10 mM and is 100-fold selective over glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice.²It reduces the incidence of myoclonus in a mouse model of audiogenic seizures.³Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol in mice.⁴Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.

1.Lippert, B., Metcalf, B.W., Jung, M.J., et al.4-Amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brainEur. J. Biochem.74(3)441-445(1977) 2.Jung, M.J., Lippert, B., Metcalf, B.W., et al.g-Vinyl GABA (4-amino-hex-5-enoic acid), A new selective irreversible inhibitor of GABA-T: Effects on brain GABA metabolism in miceJ. Neurochem.29(5)797-802(1977) 3.Meldrum, B.S., and Murugaiah, K.Anticonvulsant action in mice with sound-induced seizures of the optical isomers of g-vinyl GABAEur. J. Pharm.89(1-2)149-152(1983) 4.Luszczki, J.J., and Czuczwar, S.J.Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsyProg. Neuropsychopharmacol. Biol. Psychiatry31(2)529-538(2007)