An internal standard for the quantification of fingolimod
货号:ajcx22494
CAS:1346747-38-3
分子式:C19H29D4NO2
分子量：311.5
溶解度:DMF: 20 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fingolimod-d₄is intended for use as an internal standard for the quantification of fingolimod by GC- or LC-MS. Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herbI. sinclariias well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.¹Fingolimod is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P₁, S1P₃, S1P₄, and S1P₅).²Down-regulation of S1P₁receptors on T and B lymphocytes by fingolimod results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch.³Fingolimod also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C₄transporter Abcc1 and inhibits cytosolic phospholipase A₂activity.^4,5

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