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13,14-dihydro-16,16-difluoro Prostaglandin F2α
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
13,14-dihydro-16,16-difluoro Prostaglandin F2α图片
规格:98%
分子量:392.5
包装与价格:
包装价格(元)
100ug询价
500ug询价
1mg询价

A neuropeptide with diverse biological activities
货号:ajcx21108
CAS:N/A
分子式:C20H34F2O5
分子量:392.5
溶解度:DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin F(PGF) causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.1,213,14-dihydro-16,16-difluoro PGFis an analog of PGF. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradationin vivo.3Importantly, 13,14-dihydro PGE1has activity that is comparable to that of PGE1, suggesting that this analog of PGFcould be biologically active.4,5


1.Samuelsson, B., Goldyne, M., GranstrÖm, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978) 2.Basu, S.Novel cyclooxygenase-catalyzed bioactive prostaglandin F2α from physiology to new principles in inflammationMedicinal Research Reviews27(4)435-468(2007) 3.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 4.ÄnggÅrd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 5.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)

 
 
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