叶酸-d4（维生素 B9-d4）是氘标记的叶酸。叶酸（维生素 M；维生素 B9）是一种 B 族维生素；对于新细胞的产生和维持、DNA 合成和 RNA 合成是必需的。
货号:ajcx19432
CAS:171777-72-3
分子式:C19H15D4N7O6
分子量：445.4
溶解度:DMF: 10 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Folic acid-d4 is intended for use as an internal standard for the quantification of folic acid by GC- or LC-MS. Folic acid is an essential B vitamin.1 It is converted to folate in vivo, which is a necessary cofactor for a variety of biological processes, including nucleotide synthesis and, thus, DNA synthesis and repair, among others. A deficiency in dietary folic acid can lead to a range of developmental and cognitive disorders, most prominently neural tube defects and congenital heart defects.1,2,3

参考文献
1. Czeizel, A.E., DudÁs, I., Vereczkey, A., et al. Folate deficiency and folic acid supplementation: The prevention of neural-tube defects and congenital heart defects. Nutrients 5(11), 4760-4775 (2013).
2. Nair, M.K., Augustine, L.F., and Konapur, A. Food-based interventions to modify diet quality and diversity to address multiple micronutrient deficiency. Front. Public Health 3, 277 (2016).
3. Sarmah, S., Muralidharan, P., and Marrs, J.A. Common congenital anomalies: Environmental causes and prevention with folic acid containing multivitamins. Birth Defects Res. C Embryo Today 108(3), 274-286 (2016).