UAMC-3203 是一种有效的选择性铁死亡抑制剂，IC50 为 12 nM。
货号:ajcx17520
CAS:2271358-64-4
分子式:C25H37N5O2S
分子量：471.7
溶解度:Ethanol: Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 . In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.