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KDU731
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KDU731图片
规格:98%
分子量:396.4

KDU731,具有口服活性的 C. parvum PI4K 抑制剂,阻断体内外隐孢子虫感染,IC50 值为 25 nM。KDU731 是治疗隐孢子虫引起的腹泻的有望候选药物,具有广泛的安全性。
货号:ajcx14214
CAS:1610610-48-4
分子式:C22H16N6O2
分子量:396.4
溶解度:DMSO: 83.33 mg/mL (210.22 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].


KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool[2]. Animal Model: 6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts[1]

[1]. Ward HD, et al. New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis. Trends Parasitol. 2017 Sep;33(9):662-664. [2]. Manjunatha UH, et al. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. 2017 Jun 15;546(7658):376-380.

 
 
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