SW-163D-AcLysValCit-PABC-DMAE是抗体药物复合体的一部分(Drug-LinkerConjugatesforADC),由天然的双嵌入剂SW-163D和连接桥AcLysValCitPABC-DMAE偶联构成。
货号:ajcx13556
CAS:N/A
分子式:C85H113N19O22S2
分子量：1817.05
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SW-163D-AcLysValCit-PABC-DMAE is a Drug-Linker Conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1].

SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase[1].

[1]. Ratnayake AS, et al. Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjug Chem. 2018 Dec 13. doi: 10.1021/acs.bioconjchem.8b00843.