ML-SI1 是一种非对映异构体的外消旋混合物，是一种 TRPML 抑制剂，对 TRPML1 的 IC50 值为 15 μM。
货号:ajcx12010
CAS:N/A
分子式:C??H??Cl?N?O?
分子量：449.37
溶解度:DMSO : 100 mg/mL (222.53 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1.

ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments confirmed that the synthesized racemic ML-SI1 (10 μM) has an inhibitory effect on hTRPML1[1].

参考文献:
[1]. Charlotte Leser, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.