LTA4H-IN-1 是一种有效的白三烯 A4 水解酶 LTA4H 抑制剂，IC50 值为 2 nM。LTA4H-IN-1 可用于研究炎症和自身免疫性疾病。详细信息请参考专利文献 WO2015092740A1 中的化合物 29。
货号:ajcx35674
CAS:1799681-85-8
分子式:C16H14ClFN6O3
分子量：392.77
溶解度:DMSO : 250 mg/mL (636.50 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders[1].

LTA4H-IN-1 (15 min) inhibits the hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) which is catalyzed by LTA4H, with an IC50 of 2 nM[1].LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC50 of 167 nM[1].

LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice[1].

[1]. Bollbuck B, et, al. Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2015092740A1.