DHODH-IN-11(Compound14b)是一种Leflunomide衍生物，也是一种二氢乳清酸脱氢酶(DHODH)的弱抑制剂，其pKa为5.03。
货号:ajcx30504
CAS:1263303-95-2
分子式:C15H11N3O2
分子量：265.27
溶解度:DMSO: 125 mg/mL (471.22 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].

Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].

[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.