Cefoxitin是一种广谱的、具有抗菌活性的第二代头孢菌素。Cefoxitin对革兰氏阳性/革兰氏阴性需氧菌和厌氧菌引起的各种感染都有效。
货号:ajcx30362
CAS:35607-66-0
分子式:C16H17N3O7S2
分子量：427.45
溶解度:DMSO: 100 mg/mL (233.95 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cefoxitin is a broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin is effective against a wide variety of infections caused by gram-positive or gram-negative aerobes as well as by anaerobic bacteria[1][2].

Cefoxitin has good activity against gram-positive bacteria. The MICs for several gram-positive pathogens are in the range of 1-6 μg/mL[1].Cefoxitin has shown high efficacy killing B. burgdorferi at concentration of 1.25 µM/mL[3].

Cefoxitin (20 mg/kg; i.p.; daily; for 5 days) effectively kills B. burgdorferi in vivo C3H/HeN mouse model[3]. Animal Model: Four-week-old female C3H/HeN mice[3]

[1]. E O Stapley, et al. Cefoxitin and cephamycins: microbiological studies. Rev Infect Dis. Jan-Feb 1979;1(1):73-89. [2]. R N Brogden, et al. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979 Jan;17(1):1-37. [3]. Venkata Raveendra Pothineni, et al. In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des Devel Ther. 2018; 12: 2915-2921.