MisoprostolacidD5是Misoprostolacid的氘代物。Misoprostolacid是一种Misoprostol的活性代谢物。Misoprostol是前列腺素E1(PGE1)的合成类似物，被广泛吸收，口服后迅速在胃肠道中转化成Misoprostolacid。Misoprostol可用于非甾体类抗炎药诱发的(NSAID)胃溃疡，还可用于引产的研究。
货号:ajcx29508
CAS:1337917-44-8
分子式:C21H31D5O5
分子量：373.54
溶解度:DMF: >100 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Misoprostol acid D5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

[1]. Vijaya Bharathi D, et al. Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2827-33. [2]. Schmidt-Hansen M, et al. Simultaneous compared to interval administration of mifepristone and misoprostol for medical abortion up to 10+0 weeks' gestation: a systematic review with meta-analyses. BMJ Sex Reprod Health. 2020 Feb 20. pii: bmjsrh-2019-200448.