EED226-COOH 是一种基于 EED226 的 PROTAC 靶蛋白 EED 配体，通过 linker 与 VHL 配体结合形成 PRC2 降解剂 UNC6852 。
货号:ajcx29306
CAS:2467965-71-3
分子式:C17H13N5O3
分子量：335.32
溶解度:DMSO: 125 mg/mL (372.78 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.