Potent and selective BRD9 degrading PROTAC
货号:ajcx27716
CAS:2341840-98-8
分子式:C40H45N7O10.2HCl
分子量：856.75
溶解度:Water 17.14 mg/ml, DMSO 42.84 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC? composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . Potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID:28418626