A peptide ETB receptor antagonist
货号:ajcx26686
CAS:N/A
分子式:C96H140N20O25S • XCF3COOH
分子量：2006.3
溶解度:DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BQ-3020 is a peptide endothelin type B (ET_B) receptor agonist.¹It selectively binds to ET_Bover ET_Areceptors (IC₅₀s = 0.07 and 940 nM, respectively) and induces inositol triphosphate formation and calcium mobilization in isolated bovine carotid artery endothelial cells.^1,2BQ-3020 increases or decreases renal perfusion pressure in Dahl salt-resistant or -sensitive rats, respectively.³It decreases the production of nitric oxide (NO) and induces vasoconstriction in a rat model of diet-induced hypercholesterolemia.

1.Ihara, M., Saek, T., Fukuroda, T., et al.A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptorsLife Sci.51(6)PL47-PL52(1992) 2.Hirata, Y., Emori, T., Eguchi, S., et al.Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cellsJ. Clin. Invest.91(4)1367-1373(1993) 3.Kakoki, M., Hirata, Y., Hayakawa, H., et al.Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidneyCirculation99(9)1242-1248(1999)