An anticancer agent
货号:ajcx26276
CAS:2345755-20-4
分子式:C10H15Cl2InN4OS
分子量：425
溶解度:DMF: 10 mg/mL,DMF:PBS (pH 7.2) (1:2): 0.30 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Indium (III) thiosemicarbazone 5b is an anticancer agent.¹It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC₅₀s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells.In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.

1.Jiang, M., Chu, Y., Yang, T., et al.Developing a novel indium(III) agent based on liposomes to overcome cisplatin-induced resistance in breast cancer by multitargeting the tumor microenvironment componentsJ. Med. Chem.64(19)14587-14602(2021)