An internal standard for the quantification of roxatidine
货号:ajcx25248
CAS:N/A
分子式:C17H16D10N2O3·1/2C2H2O4
分子量：361.5
溶解度:DMSO: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Roxatidine-d₁₀is intended for use as an internal standard for the quantification of roxatidine by GC- or LC-MS. Roxatidine is a histamine H₂receptor antagonist and major active metabolite of roxatidine acetate .¹Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC₅₀= 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA₂= 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin .²

1.Sewing, K.-F., Beil, W., and Hannemann, H.Comparative pharmacology of histamine H2-receptor antagonistsDrugs35(Suppl. 3)25-29(1988) 2.Umegaki, E., Yoda, Y., Tokioka, S., et al.Protective effect of roxatidine against indomethacininduced small intestinal mucosal injury in ratsJ. Gastroenterol. Hepatol.25(Suppl. 1)S35-S40(2010)