7-Methoxyflavone 是一种从 Zornia brasiliensis 中分离出来的化合物。
货号:ajcx24766
CAS:22395-22-8
分子式:C16H12O3
分子量：252.3
溶解度:DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

7-Methoxyflavone is a flavone that has been found inZ. brasiliensisand has diverse biological activities.^1,2,3,4It inhibits aromatase (IC₅₀= 1.9 µM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 µM.^1,27-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED₅₀= 82.5 µmol/kg).^3,4

1.Ta, N., and Walle, T.Aromatase inhibition by bioavailable methylated flavonesJ. Steroid. Biochem. Mol. Biol.107(1-2)127-129(2007) 2.An, J.-Y., Lee, H.-H., Shin, J.-S., et al.Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cellsBioorg. Med. Chem. Lett.27(11)2613-2616(2017) 3.Nishizaki, Y., Ishimoto, Y., Hotta, Y., et al.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assayBioorg. Med. Chem. Lett.19(16)4706-4710(2009) 4.da Silva, A.D.S., Cavalcante-Silva, L.H.A., da Matta, C.B.B., et al.Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensisNat. Prod. Res.27(18)1695-1699(2013)