An acridone alkaloid with antimalarial and anticancer activities
货号:ajcx24588
CAS:568-01-4
分子式:C17H15NO5
分子量：313.3
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Melicopine is an acridone alkaloid that has been found inZ. simulansand has antimalarial and anticancer activities.¹It is active against the chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains ofP. falciparumwith IC₅₀values of 29.7 and 33.7 µg/ml, respectively. Melicopine is cytotoxic to PC-3M and LNCaP prostate cancer, but not non-cancerous HEK293, cells (IC₅₀s = 47.9, 37.8, and >100 µg/ml, respectively).

1.Wang, C., Wan, J., Mei, Z., et al.Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans HancePharmacogn. Mag.10(37)73-76(2014)