C16[13C]H12D3FN6O3
货号:ajcx24398
CAS:N/A
分子式:C16[13C]H12D3FN6O3
分子量：374.4
溶解度:Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tedizolid-¹³C-d₃is intended for use as an internal standard for the quantification of tedizolid by GC- or LC-MS. Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate .¹Tedizolid phosphate is converted to tedizolid by phosphatasesin vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistantS. aureus(MRSA),E. faecalis, and penicillin-susceptibleS. pneumoniae(MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptibleS. aureus(MSSA) infection (ED₅₀= 8.8 mg/kg).²

1.Schaadt, R., Sweeney, D.A., Shinabarger, D., et al.In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agentAntimicrob. Agents Chemother.53(8)3236-3239(2009) 2.Im, W.B., Choi, S.H., Park, J.-Y., et al.Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agentEur. J. Med. Chem.46(4)1027-1039(2011)